منابع مشابه
[Genetics of autism: from genome scans to candidate genes].
The autistic disorder was firstly described by Leo Kanner sixty years ago. This complex developmental disability is characterized by social and communicative impairments and repetitive and stereotyped behaviours and interests. The prevalence of autism in the general population is about 1 in 1,000, with four males affected for one female. In approximately 15% of the cases, autism is associated w...
متن کاملAssociation and Mutation Analyses of 16p11.2 Autism Candidate Genes
BACKGROUND Autism is a complex childhood neurodevelopmental disorder with a strong genetic basis. Microdeletion or duplication of a approximately 500-700-kb genomic rearrangement on 16p11.2 that contains 24 genes represents the second most frequent chromosomal disorder associated with autism. The role of common and rare 16p11.2 sequence variants in autism etiology is unknown. METHODOLOGY/PRIN...
متن کاملCandidate Genes for Inherited Autism Susceptibility in the Lebanese Population
Autism spectrum disorder (ASD) is characterized by ritualistic-repetitive behaviors and impaired verbal/non-verbal communication. Many ASD susceptibility genes implicated in neuronal pathways/brain development have been identified. The Lebanese population is ideal for uncovering recessive genes because of shared ancestry and a high rate of consanguineous marriages. Aims here are to analyze for ...
متن کاملSleeping Beauty Mouse Models Identify Candidate Genes Involved in Gliomagenesis
Genomic studies of human high-grade gliomas have discovered known and candidate tumor drivers. Studies in both cell culture and mouse models have complemented these approaches and have identified additional genes and processes important for gliomagenesis. Previously, we found that mobilization of Sleeping Beauty transposons in mice ubiquitously throughout the body from the Rosa26 locus led to g...
متن کاملGenetic‐Genomic Replication to Identify Candidate Mouse Atherosclerosis Modifier Genes
OBJECTIVE Genetics plays a large role in atherosclerosis susceptibility in humans and mice. We attempted to confirm previously determined mouse atherosclerosis-associated loci and use bioinformatics and transcriptomics to create a catalog of candidate atherosclerosis modifier genes at these loci. METHODS AND RESULTS A strain intercross was performed between AKR and DBA/2 mice on the apoE(-/-)...
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ژورنال
عنوان ژورنال: Journal of Biomedical Informatics
سال: 2011
ISSN: 1532-0464
DOI: 10.1016/j.jbi.2011.03.003